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Capecitabine is FDA-approved for:

Adjuvant in colorectal cancer Stage III Dukes’ C - used as first-line monotherapy.
Metastatic colorectal cancer - used as first-line monotherapy, if appropriate.
Metastatic breast cancer - used in combination with docetaxel, after failure of anthracycline-based treatment. Also as monotherapy, if the patient has failed paclitaxel-based treatment, and if anthracycline-based treatment has either failed or cannot be continued for other reasons (i.e., the patient has already received the maximum lifetime dose of an anthracycline).

In the UK, capecitabine is approved by the National Institute for Health and Clinical Excellence (NICE) for colon and colorectal cancer, and locally advanced or metastatic breast cancer[1].

Potential major adverse reactions include:

Cardiovascular: EKG changes, myocardial infarction, angina (these may be more common in patients with pre-existing coronary artery disease)
Dermatological: Hand-foot syndrome (numbness, tingling, pain, redness, or blistering of the palms of the hands and soles of the feet)
Gastrointestinal: Diarrhea (sometimes severe), nausea, stomatitis
Hematological: Neutropenia, anemia, thrombocytopenia
Hepatic: Hyperbilirubinemia

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Business Editors and Health/Medical Writers

Irvine, Calif.–(BW HealthWire)–Jan. 4, 2001

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Courtney Love is the most charismatic and talented rock diva to have appeared since Debbie Harry. You can more or less write off most of the customised babes who popped up and vanished in between. Poppy Z Brite is a writer of spectral and intoxicating Gothic novels. As Courtney Love’s biographer, she is heaven sent. She gives Love’s life the hot and febrile treatment it deserves.

Brite counteracts more sensational treatments; her approach to her subject is frank, often droll, but always girl-friendly. In the roll-call of feminine icons, Love has embodied an almost supernatural ferocity mixed with tenderness, a maternal edge with powerful sexuality. She’s a grunge Marilyn, but with a strong survivalist seam, dangerous enough to be vilified. Her background is as ragged as those kinder-whore nighties she used to wear, and her road to fame wasn’t easy.

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New data linking paroxetine use during the first trimester of pregnancy with increased risk of major congenital malformations has prompted changes to the drug’s label. Preliminary results of a retrospective epidemiologic study sponsored by GlaxoSmithKline Inc., the drug’s maker, show paroxetine (marketed as Paxil), was associated with more congenital malformations (adjusted odds ratio 2.20) and more cardiovascular malformations (adjusted odds ratio 2.08) than other antidepressants in almost 3,600 pregnant women.

GlaxoSmithKline (NYSE: GSK) today announced the U.S. Food and Drug Administration (FDA) approved the company’s Supplemental New Drug Application (SNDA) for an intermittent dosing regimen of Paxil CR™ (paroxetine HCl) Controlled-Release Tablets for the treatment of premenstrual dysphoric disorder (PMDD). With the new dosing option, women suffering from PMDD can take Paxil CR once-daily during the two-week period prior to the onset of their menstrual cycle rather than throughout the month. Paxil CR, the first and only controlled-release SSRI indicated for intermittent treatment of PMDD, is also indicated for the continuous treatment of PMDD, depression, social anxiety disorder and panic disorder.

Affecting more than five million women of reproductive age in the U.S., PMDD is a severe form of PMS that can significantly impair a woman’s ability to carry out daily activities. It is characterized by intense emotional symptoms including severely depressed mood, irritability and tension, as well as the debilitating physical symptoms associated with the menstrual cycle.

“In my experience, women like the flexibility of taking their medication during the two weeks they would normally experience the worst of their symptoms,” said Kimberly A. Yonkers, M.D., Associate Professor of Psychiatry, Yale University of Medicine and lead investigator of the largest clinical trial database of PMDD patients. “The new dosing option with Paxil CR is appealing because patients can achieve relief from the debilitating physical and emotional symptoms of PMDD at a low dosHow to quit paxil
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NEW YORK — The United States hasn’t entirely ruled out overriding Bayer’s Cipro (ciprofloxacin) patent, which is due to expire in the U.S. market in December 2003, and some generic antibiotic makers already are reaping the benefits of federal willingness to buy older antibiotics that fight anthrax equally well.

Sen. Charles Schumer, D-N.Y., is calling on the U.S. Department of Health and Human Services to contract directly with generic Cipro manufacturers in an attempt to increase existing Cipro supply and decrease its cost. He has said publicly that he doubts Bayer will meet production goals and hinted free market Cipro prices have risen sharply above the prewar price of $3.20 per pill. HHS secretary Tommy Thompson recently was able to bargain Bayer down to 95 cents per pill for sale to the federal government.

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Grünenthal, which still owns the patent to tramadol, has cross-licensed the agent to pharmaceutical companies internationally. Thus, tramadol is marketed under many trade names around the world, including:

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Novartis Pharmaceuticals Corporation announced today it has expanded its Diovan(R) (valsartan) franchise by adding a new Diovan HCT(R) dosing strength that provides impressive reductions in both systolic and diastolic blood pressure. The new addition of Diovan HCT (valsartan/hydrochlorothiazide) 160/25mg tablets creates the broadest dosing range of any angiotensin receptor blocker (ARB)/diuretic therapy marketed. The availability of Diovan HCT 160/25 mg provides physicians with more treatment options for patients that require additional blood pressure control beyond that provided with Diovan or hydrochlorothiazide (HCTZ) monotherapy. Diovan is one of the fastest growing agents among the top 10 branded prescription antihypertensives on the market today, and leading angiotensin receptor blocker (ARB) franchise in the U.S.

The efficacy of Diovan HCT has been studied in controlled clinical trials involving more than 1,500 patients. Studies demonstrated the combination of Diovan 160 mg and HCTZ 25 mg significantly decreased both systolic and diastolic blood pressure when compared to the individual medications, Diovan and HCTZ. The combination of Diovan 160 mg and HCTZ 25 mg resulted in a 21 mmHg and 11 mmHg reduction in systolic and diastolic blood pressure compared to a 10 mmHg and a 6 mmHg reduction for Diovan 160 mg alone; and a 10 mmHg and 5 mmHg reduction What is diovan hci
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Acylovir is active against most species in the herpesvirus family. In descending order of activity:[1]

Herpes simplex virus type I (HSV-1)
Herpes simplex virus type II (HSV-2)
Varicella zoster virus (VZV)
Epstein-Barr virus (EBV)
Cytomegalovirus (CMV)

Activity is predominantly against HSV, and to a lesser extent VZV. It is only of limited efficacy against EBV and CMV. It is inactive against latent viruses in nerve ganglia.
To date, resistance to aciclovir has not been clinically significant. Mechanisms of resistance in HSV include deficient viral thymidine kinase; and mutations to viral thymidine kinase and/or DNA polymerase, altering substrate sensitivity.[2]

Aciclovir topical cream is commonly associated (≥1% of patients) with: dry or flaking skin and/or transient stinging/burning sensations. Infrequent adverse effects include erythema and/or itch.[3]
When applied to the eye, aciclovir is commonly associated (≥1% of patients) with transient mild stinging. Infrequently (0.1–1% of patients), ophthalmic aciclovir is associated with superficial punctate keratitis and/or allergic reactions.[3]

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Combination therapies have been used to treat several conditions, the theory being that combining drugs with different mechanisms may convey added benefits. That same belief is behind Vytorin, a combination of ezetimibe (Zetia) and simvastatin (Zocor) used to lower cholesterol, a chief risk factor for heart disease. Simvastatin is one of several statin drugs that help reduce the amount of cholesterol your body produces. Ezetimibe is designed to lower the amount of cholesterol absorbed through your small intestine.

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YARDLEY, Pa. — For the first time since its launch, the combination drug Vytorin led the cholesterol reducer market in projected switch/add patient transactions for the week ending Jan. 14, according to Verispan’s Vector One(TM): National. Vytorin captured 21.4% of the switches, or 19,355 patient transactions, that occurred during the week.

Vector One: National provides weekly Instant View reports 5 days post-period and monthly reports 10 to 14 days post-period. Vector One’s True Patient Measures utilize de-identified patient records to uniquely pinpoint projected new patient starts, product switches and additions, continuing patients, and a host of other powerful metrics at the individual prescriber level.

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GlaxoSmithKline advises that bupropion should not be prescribed to individuals with epilepsy or other conditions that lower the seizure threshold, such as alcohol or benzodiazepine discontinuation, anorexia nervosa, bulimia, or active brain tumors. It should be avoided in individuals who are also taking MAO inhibitors (MAOIs). When switching from MAOIs to bupropion, it is important to include a washout period of about two weeks between the medications.[52] The prescribing information approved by the FDA recommends that caution should be exercised when treating patients with liver damage, severe kidney disease, and severe hypertension, as well as in pediatric patients, adolescents and young adults due to the increased risk of suicidal ideation.[52]
According to a retrospective case series published in 1993, bupropion treatment may exacerbate tics in children with co-occurring ADHD and Tourette syndrome.[53] No further research of this side effect has been conducted.

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Testosterone injections are becoming increasingly popular among those who are looking to increase their levels of this vital hormone.

Indeed, injectable testosterone is one of the most cost effective methods out of the available testosterone replacement therapies. Moreover, the injections are easily administered (by either the doctor or yourself), and then you’re all set for a few weeks.

Besides needing to administer the testosterone, you’ll need to purchase the proper equipment you’ll need to inject the hormone. The actual medication itself comes in 10cc bottles — one of which will last you around 15 weeks, if you’re using the regular dosage of 200mg. The cost of one of these bottles? Around ten dollars.

Just how easy are they to use? Unlike testosterone patches, where you must go through the ordeal of shaving your scrotum and then applying the patch using a blow dryer, you simply have to give yourself a shot. The vast majority of doctors will teach their patients how to administer the shot properly, making your job that much easier.

Testosterone injections

Another benefit of using injectable testosterone is that you only have to administer the shot once every two or three weeks. Compare that to the testosterone patch — which you generally must change every 24 hours, or to orally taken pills — which you have to take several of every day, and it seems like testosterone injections are the way to go.

However, before you conclude injections are indeed best, understand that it has its fair share of negatives as well.

There are all the little downsides of having to give yourself a shot, which can be painful and can leave muscles sore near the site of injection; even worse is the emotional swings you may feel.

Think of a “Mountain/Valley” metaphor.

Meaning, when you first get the injectable testosterone, you’re getting a highly concentrated dose of this hormone right into your body. Because of that, your testosterone levels will be high for the first few days after the injection.

You’ll more than likely experience a significant boost of energy, increased sexual desire, more assertiveness, and better mood.

However, because you’re taking one highly concentrated dose, it may also raise your aggressiveness, and leave you more prone to mood swings - a very alarming combination.

We just described the mountain part of the metaphor.

Now for the valley. The valley is not fun. Like all things, what goes up must come down. A week or so after the initial boost of testosterone, your levels of the hormone will begin to taper off.

You’ll begin to feel lethargic, have less sexual desire, and your high spirits may drop drastically.

The valley logically is at its worst the days before your next injection because your testosterone levels may have fallen off by then quite a bit.

Does this mountain/valley syndrome happen to everyone? No, it doesn’t. The only way to know is to consult your physician who will monitor you. Either way, you’ll have to consult your doc if you want him to prescribe you testosterone injections.

The point here is that there are pros and cons of any of the available testosterone replacement therapies.

Although testosterone injections may seem great at first, do research on the other prescription testosterone boosting methods at the resources given below.

In addition, there are even natural ways to boost your testosterone that require no prescription at all.

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