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Because amiodarone has a low incidence of pro-arrhythmic effects, it has been used both in the treatment of acute life-threatening arrhythmias as well as the chronic suppression of arrhythmias. It is useful both in supraventricular arrhythmias and ventricular arrhythmias.
Amiodarone is extensively metabolized in the liver, and can affect the metabolism of numerous other drugs. The major metabolite of amiodarone is desethylamiodarone (DEA), which also has antiarrhythmic properties. The metabolism of amiodarone is inhibited by grapefruit juice, leading to elevated serum levels of amiodarone.
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^ Drug Approval Package. Retrieved on 2007-09-30.
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^ British National Formulary guidance on thyroid function monitoring (BNF Amiodarone)
^ a b Batcher EL, Tang XC, Singh BN, Singh SN, Reda DJ, Hershman JM (Oct 2007). “Thyroid function abnormalities during amiodarone therapy for persistent atrial fibrillation”. Am J Med 120 (10): 880-85. doi:10.1016/j.amjmed.2007.04.022.
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